Geneva Biotech releases the first efficient non-lentiviral transduction system for immortal T-cells and B-cells. Please see Mammalian Product Category “T-Cells B-Cells”
Replication fork protection by BRCA1–BARD1 revealed in Nature
The cryo-EM structure of Pan2-Pan3 in complex with a poly(A) RNP published in Cell provides molecular insights into the process of poly(A) tail shortening
BRISC–SHMT2 interactions are key to immune regulation as revealed in Nature
Many of Geneva Biotech’s industry leading baculoviral genomes are now available as competent cells in Europe, Asia, and North America !
Structure and regulation of key chromatin remodelling enzyme INO80 revealed in Nature
Protein-Protein interactions (PPIs) are central to most essential cellular mechanisms including gene expression, protein translocation, cell cycle progression and signal transduction. Bellón-Echeverría et al. published in Scientific Reports a proof of concept employing MultiBacMam to identify new small-molecule inhibitors of the CDK5-p25 protein-protein interaction. The method is generally applicable to any multiprotein cascade important in drug discovery.
Stolt-Bergner et al. published in Journal of Structural Biology a benchmarking initiative in 13 independent labs to compare the world’s leading baculovirus expression systems. Geneva Biotech’s EMBacY virus was ranked #1 in performance.
Tchesnokov et al. published in Scientific Reports (DOI: :10.1038/s41598-018-22328-3) a production system for Ebola Virus RNA-Dependent RNA Polymerase Complex using the MultiBac system, providing a powerful discovery system for this key drug target.
Geneva Biotech and Sphere Fluidics launch R&D project to develop methods that enable large DNA cargo delivery and genome engineering in primary cells that have proven refractory to traditional transfection, electroporation, or transduction methods. LINK