Geneva Biotech is delighted to announce better services for our customers in China by teaming up with Equl LTD who have locations in Honk Kong and Shanghai LINK to EQUL
Geneva Biotech releases the first efficient non-lentiviral transduction system for immortal T-cells and B-cells. Please see Mammalian Product Category “T-Cells B-Cells”
Many of Geneva Biotech’s industry leading baculoviral genomes are now available as competent cells in Europe, Asia, and North America !
Protein-Protein interactions (PPIs) are central to most essential cellular mechanisms including gene expression, protein translocation, cell cycle progression and signal transduction. Bellón-Echeverría et al. published in Scientific Reports a proof of concept employing MultiBacMam to identify new small-molecule inhibitors of the CDK5-p25 protein-protein interaction. The method is generally applicable to any multiprotein cascade important in drug discovery.
Stolt-Bergner et al. published in Journal of Structural Biology a benchmarking initiative in 13 independent labs to compare the world’s leading baculovirus expression systems. Geneva Biotech’s EMBacY virus was ranked #1 in performance.
Tchesnokov et al. published in Scientific Reports (DOI: :10.1038/s41598-018-22328-3) a production system for Ebola Virus RNA-Dependent RNA Polymerase Complex using the MultiBac system, providing a powerful discovery system for this key drug target.
Geneva Biotech and Sphere Fluidics launch R&D project to develop methods that enable large DNA cargo delivery and genome engineering in primary cells that have proven refractory to traditional transfection, electroporation, or transduction methods. LINK
Geneva Biotech and partners have recorded >70% increase in baculovirus DNA stability in scale up experiments to 100L using second generation SynBac genomes. DNA stability was found to strongly correlate (r = 0.91) with expression yield of multiple different test proteins.
Intact Genomics is a world leader of ultra-high competent cell production and BAC (bacterial artificial chromosome) library related technologies. Intact has partnered with Geneva Biotech to offer North American customers competent cells containing Geneva Biotech’s viral genomes. See their Geneva Biotech partnered products here INTACT GENOMICS
Aylett et al. published in Science (DOI: 10.1126/science.aaa3870) the structure of key drug target mTORC1 using the MultiBac system, providing critical information on the function and intricate regulation of this important enzyme which is implicated in common human diseases including cancer and diabetes.