Geneva Biotech is a privately held biotechnology company, based in Geneva, Switzerland. Founded in 2012

Geneva Biotech Hormone Receptor Factory™

Intelligent DNA delivery systems

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Hormone Receptor Factory™

Technology Description


In the pharma and biotech industries, steroid receptors are mainly produced using baculovirus with only a small fraction amenable to production using E.coli. The reason for this is steroid receptors produced in E.coli are typically misfolded and are unsuitable for drug screening since the Hsp90 chaperone system is required for their native folding and biological activity. Though E.coli has Hsp90, it is evolutionarily distant from mammalian Hsp90 and cannot facilitate the native folding of mammalian Hsp90-dependent proteins. Due to cost versus yield, mammalian protein expression systems are hardly ever used for commercial production of steroid receptors.

We have developed baculoviral genomes with integrated copies of entire chaperone machineries comprising up to 7 co-expressed chaperone proteins built around a Hsp90 core. The components were selected from the literature to boost solubility and yield of a broad variety of human steroid receptors.


Use MultiBac™ protocols (click here) to assemble Hormone Receptor Factory™ Viruses

Click here for DNA vector sequences

Click here to download Cre-ACEMBLER for Windows

Click here to download Cre-ACEMBLER for Linux

Click here to download Cre-ACEMBLER User Manual 3.0

Click here to download Cre-ACEMBLER Short Description


HR Factory™ System Kit 1,490.00€ ENQUIRY

Chemically Competent Cells

ig™ 10B (12 X 100µl) 760.00€ ENQUIRY
PirHC (12 x 100µl) 960.00€ ENQUIRY


pACEBac1 (5µg) 279.00€ ENQUIRY
pACEBac2 (5µg) 279.00€ ENQUIRY
pIDK (5µg) 279.00€ ENQUIRY
pIDC (5µg) 279.00€ ENQUIRY
pIDS (5µg) 279.00€ ENQUIRY

Dual Plasmids

pFL (5µg) 319.00€ ENQUIRY
pKL (5µg) 319.00€ ENQUIRY
pSPL (5µg) 319.00€ ENQUIRY
pUCDM (5µg) 319.00€ ENQUIRY

Dual Mammalian Insect Cell Plasmids

pFL-IM (5µg) 419.00€ ENQUIRY
pKL-IM (5µg) 419.00€ ENQUIRY
pSPL-IM (5µg) 419.00€ ENQUIRY
pUCDM-IM (5µg) 419.00€ ENQUIRY


E.coli cell expression

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