Geneva Biotech is a privately held biotechnology company, based in Geneva, Switzerland. Founded in 2012

Geneva Biotech Hormone Receptor Factory™

Intelligent DNA delivery systems

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Hormone Receptor Factory™

Technology Description

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In the pharma and biotech industries, steroid receptors are mainly produced using baculovirus with only a small fraction amenable to production using E.coli. The reason for this is steroid receptors produced in E.coli are typically misfolded and are unsuitable for drug screening since the Hsp90 chaperone system is required for their native folding and biological activity. Though E.coli has Hsp90, it is evolutionarily distant from mammalian Hsp90 and cannot facilitate the native folding of mammalian Hsp90-dependent proteins. Due to cost versus yield, mammalian protein expression systems are hardly ever used for commercial production of steroid receptors.

We have developed baculoviral genomes with integrated copies of entire chaperone machineries comprising up to 7 co-expressed chaperone proteins built around a Hsp90 core. The components were selected from the literature to boost solubility and yield of a broad variety of human steroid receptors.

Downloads

Use MultiBac™ protocols (click here) to assemble Hormone Receptor Factory™ Viruses

Click here to download Cre-ACEMBLER User Manual v2.0

Click here to download Cre-ACEMBLER Short Description

Click here to download Cre-ACEMBLER for Windows (32bit)

Click here to download Cre-ACEMBLER for Linux

Kits

HR Factory™ System Kit 1,149.00€ ENQUIRY

Cell Lines

DH10 HR 1.0 819.00€ ENQUIRY
DH10 HR 2.0 819.00€ ENQUIRY
PirHC 279.00€ ENQUIRY
PirLC 279.00€ ENQUIRY

Plasmids

pACEBac1 (5µg) 279.00€ ENQUIRY
pACEBac2 (5µg) 279.00€ ENQUIRY
pIDK (5µg) 279.00€ ENQUIRY
pIDC (5µg) 279.00€ ENQUIRY
pIDS (5µg) 279.00€ ENQUIRY

Dual Plasmids

pFL (5µg) 319.00€ ENQUIRY
pKL (5µg) 319.00€ ENQUIRY
pSPL (5µg) 319.00€ ENQUIRY
pUCDM (5µg) 319.00€ ENQUIRY

Dual Mammalian Insect Cell Plasmids

pFL-IM (5µg) 419.00€ ENQUIRY
pKL-IM (5µg) 419.00€ ENQUIRY
pSPL-IM (5µg) 419.00€ ENQUIRY
pUCDM-IM (5µg) 419.00€ ENQUIRY

Enquiry

E.coli cell expression
MultiColi™

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