ManuBac™ : Virion Free Protein Production
Baculovirus is a leading methodology for producing virus like particle (VLP) vaccines. Traditional baculovirus expression systems co-produce baculovirus virions together with the VLP. Separation of VLPs from contaminating virions is costly, and adds an additional regulatory risk in the development of biopharmaceuticals. ManuBac™ solves this problem by allowing virion-free VLP production.
ManuBac™ is under development and will be available in 2017.
ManuBac™ vs. Traditional Baculovirus Production of VLPs. During traditional production of VLPs using baculovirus (top), virions (blue dots) are produced together with the VLP (red dots). ManuBac™ (bottom) takes advantage of iBac™ induction switches to turn off production of baculovirions at the same time VLP production is turned on.
