Geneva Biotech is a privately held biotechnology company, based in Geneva, Switzerland. Founded in 2012

Geneva Biotech ComplexLINK™

Intelligent DNA delivery systems

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ComplexLINK™

Technology Description

ComplexLink™ is a system of polyprotein production combined with co-production of sequence-specific proteases that co-translationally cleave the polyprotein into functional monomeric subunits. The technology provides unique advantages over existing expression systems for production of multiprotein complexes where subunit stoichiometry is difficult to control. The technology was applied to produce recombinant influenza polymerase complex from a self-processing polyprotein, as recently published in Nature (see links below).

How ComplexLINK™ Works:

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User Manual and Other Downloads

Click here for DNA vector sequences

Click here to download Cre-ACEMBLER User Manual 3.0

Click here to download Cre-ACEMBLER Short Description

Influenza Polymerase Polyproteins

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ComplexLINK™ Influenza Polymerase Polyproteins:

The influenza polymerase remained inaccessible for decades – the challenge to produce this highly complicated protein complex for detailed analysis, proved to be a seemingly insurmountable technical challenge. The break-through studies, from the European Molecular Biology Labs, used Geneva Biotech co-founder Imre Berger’s ComplexLINK technology to produce recombinant influenza polymerase complex from a self-processing polyprotein, as recently published in Nature (links below).

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Kits

ComplexLINK™ Kit + Competent Cells 1,490.00€ ENQUIRY

Chemically Competent Cells

DH10MultiBac™ (12 x 100µl) 960.00€ ENQUIRY
ig™ 10B (12 X 100µl) 760.00€ ENQUIRY
PirHC (12 x 100µl) 960.00€ ENQUIRY

Plasmids

pPBac (5µg) 419.00€ ENQUIRY
pKL-PBac (5µg) 419.00€ ENQUIRY
pOmni-PBac (5µg) 419.00€ ENQUIRY

Flu Polymerase Polyprotein Vectors

FluB (human)
Reich et al. 2014, Nature.
Please enquire on pricing ENQUIRY
FluA (bat)
Pflug et al. 2014, Nature.
Please enquire on pricing ENQUIRY

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E.coli cell expression
MultiColi™

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