Geneva Biotech is a privately held biotechnology company, based in Geneva, Switzerland. Founded in 2012

Geneva Biotech Kinase Factory™

Intelligent DNA delivery systems

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Kinase Factory™

Technology Description

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In the pharma and biotech industries, protein kinases are mainly produced using baculovirus with only a small fraction amenable to production using E.coli. The reason for this is twofold: i) E.coli. production often does not result in high levels of soluble protein for this conformationally flexible class of proteins ii) the majority of protein kinases are inactive if produced in E.coli since they lack the post translational modification (phosphorylation) required for activity. Due to cost versus yield, mammalian protein expression systems are hardly ever used for commercial production of steroid receptors and kinases

We have developed baculoviral genomes with integrated copies of entire chaperone machineries comprising up to 7 co-expressed chaperone proteins built around a Hsp90 core. The components were selected from the literature to boost solubility and yield of a broad variety of human protein kinases.

Downloads

Use MultiBac™ protocols (click here) to assemble Kinase Factory™ Viruses

Click here to download Cre-ACEMBLER User Manual v2.0

Click here to download Cre-ACEMBLER Short Description

Click here to download Cre-ACEMBLER for Windows (32bit)

Click here to download Cre-ACEMBLER for Linux

Kits

Kinase Factory™ Expression System Kit 1,149.00€ ENQUIRY

Cell Lines

DH10 Kinase Factory 1.0 819.00€ ENQUIRY
DH10 Kinase Factory 2.0 819.00€ ENQUIRY
PirLC 279.00€ ENQUIRY
PirHC 279.00€ ENQUIRY

Plasmids

pACEBac1 (5µg) 279.00€ ENQUIRY
pACEBac2 (5µg) 279.00€ ENQUIRY
pIDK (5µg) 279.00€ ENQUIRY
pIDC (5µg) 279.00€ ENQUIRY
pIDS (5µg) 279.00€ ENQUIRY

Dual Plasmids

pFL (5µg) 319.00€ ENQUIRY
pKL (5µg) 319.00€ ENQUIRY
pSPL (5µg) 319.00€ ENQUIRY
pUCDM (5µg) 319.00€ ENQUIRY

Dual Mammalian Insect Cell Plasmids

pFL-IM (5µg) 419.00€ ENQUIRY
pKL-IM (5µg) 419.00€ ENQUIRY
pSPL-IM (5µg) 419.00€ ENQUIRY
pUCDM-IM (5µg) 419.00€ ENQUIRY

Enquiry

E.coli cell expression
MultiColi™

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